Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles

Zinc oxide (ZnO) is known to induce lung toxicity, including terminal bronchiolar epithelial hyperplasia, which gives rise to concerns that nanosized ZnO (nZnO) might lead to lung carcinogenesis. We studied the tumor promoting activity of nZnO by an initiation–promotion protocol using human c-Ha-ras...

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Detalhes bibliográficos
Main Authors: Xu, Jiegou, Futakuchi, Mitsuru, Alexander, David B., Fukamachi, Katsumi, Numano, Takamasa, Suzui, Masumi, Shimizu, Hideo, Omori, Toyonori, Kanno, Jun, Hirose, Akihiko, Tsuda, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2013
Assuntos:
Inorganic Compounds
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889829/
https://ncbi.nlm.nih.gov/pubmed/23832296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-013-1086-5
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