Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles

Zinc oxide (ZnO) is known to induce lung toxicity, including terminal bronchiolar epithelial hyperplasia, which gives rise to concerns that nanosized ZnO (nZnO) might lead to lung carcinogenesis. We studied the tumor promoting activity of nZnO by an initiation–promotion protocol using human c-Ha-ras...

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Autors principals: Xu, Jiegou, Futakuchi, Mitsuru, Alexander, David B., Fukamachi, Katsumi, Numano, Takamasa, Suzui, Masumi, Shimizu, Hideo, Omori, Toyonori, Kanno, Jun, Hirose, Akihiko, Tsuda, Hiroyuki
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2013
Matèries:
Inorganic Compounds
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889829/
https://ncbi.nlm.nih.gov/pubmed/23832296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-013-1086-5
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