Putting Pleiotropy and Selection into Context Defines a New Paradigm for Interpreting Genetic Data

BACKGROUND: Natural selection shapes many human genes, including some related to complex diseases. Understanding how selection affects genes, especially pleiotropic ones, may be important in evaluating disease associations and the role played by environmental variation. This may be of particular int...

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Detalhes bibliográficos
Main Authors: Predazzi, Irene M., Rokas, Antonis, Deinard, Amos, Schnetz-Boutaud, Nathalie, Williams, Nicholas D., Bush, William S., Tacconelli, Alessandra, Friedrich, Klaus, Fazio, Sergio, Novelli, Giuseppe, Haines, Jonathan L., Sirugo, Giorgio, Williams, Scott M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889706/
https://ncbi.nlm.nih.gov/pubmed/23616601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.113.000126
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