Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage

Detection of microbial constituents by membrane associated and cytoplasmic pattern recognition receptors is the essence of innate immunity, leading to activation of protective host responses. However, it is still unclear how immune cells specifically respond to pathogenic bacteria. Using virulent an...

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Bibliographische Detailangaben
Hauptverfasser: Ali, Syed Raza, Timmer, Anjuli M., Bilgrami, Sameera, Park, Eek Joong, Eckmann, Lars, Nizet, Victor, Karin, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889666/
https://ncbi.nlm.nih.gov/pubmed/21683629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.04.015
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