Biochemical Activities of Streptococcus pneumoniae Serotype 2 Capsular Glycosyltransferases and Significance of Suppressor Mutations Affecting the Initiating Glycosyltransferase Cps2E

The capsular polysaccharide (CPS) is essential for Streptococcus pneumoniae virulence. Its synthesis requires multiple enzymes, and defects that block completion of the pathway can be lethal in the absence of secondary suppressor mutations. In this study, we examined the functions of three capsular...

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Hlavní autoři: James, David B. A., Gupta, Kanupriya, Hauser, Jocelyn R., Yother, Janet
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889599/
https://ncbi.nlm.nih.gov/pubmed/24097952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00715-13
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