hMOF Acetylation of DBC1/CCAR2 Prevents Binding and Inhibition of SirT1

The NAD(+)-dependent deacetylase SirT1 regulates gene silencing and genomic stability in response to nutrient deprivation and DNA damage. An important regulator of SirT1 in mammalian cells is DBC1 (deleted in breast cancer 1; KIAA1967 or CCAR2), which binds to SirT1 and inhibits the deacetylation of...

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Bibliographic Details
Main Authors: Zheng, Hong, Yang, Leixiang, Peng, Lirong, Izumi, Victoria, Koomen, John, Seto, Edward, Chen, Jiandong
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889553/
https://ncbi.nlm.nih.gov/pubmed/24126058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00874-13
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