3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant

We have synthesized and characterized a series of compounds containing the 3-azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane scaffold designed as analogs of amantadine, an inhibitor of the M2 proton channel of influenza A virus. Inhibition of the wild-type (wt) M2 channel and the amantadine-resistant A/M...

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Autores principales: Rey-Carrizo, Matias, Torres, Eva, Ma, Chunlong, Barniol-Xicota, Marta, Wang, Jun, Wu, Yibing, Naesens, Lieve, DeGrado, William F., Lamb, Robert A., Pinto, Lawrence H., Vázquez, Santiago
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889466/
https://ncbi.nlm.nih.gov/pubmed/24237039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401340p
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