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Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size

The proteins that form vertebrate gap junctions, the connexins, are highly regulated and have short (<2 hour) half-lives. Phosphorylation of connexin43 (Cx43) affects gap junction assembly, channel gating and turnover. After finding dramatic effects on gap junctions with Akt inhibitors, we create...

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Bibliografske podrobnosti
Main Authors: Dunn, Clarence A., Lampe, Paul D.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889401/
https://ncbi.nlm.nih.gov/pubmed/24213533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.142497
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