Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the “adenosine hypothesis”

Schizophrenia (SZ) is a major chronic neuropsychiatric disorder characterized by a hyperdopaminergic state. The hypoadenosinergic hypothesis proposes that reduced extracellular adenosine levels contribute to dopamine D(2) receptor hyperactivity. ATP, through the action of ecto-nucleotidases, constit...

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Dettagli Bibliografici
Autori principali: Aliagas, Elisabet, Villar-Menéndez, Izaskun, Sévigny, Jean, Roca, Mercedes, Romeu, Miriam, Ferrer, Isidre, Martín-Satué, Mireia, Barrachina, Marta
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Netherlands 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889387/
https://ncbi.nlm.nih.gov/pubmed/23771238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-013-9370-7
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