Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase

BACKGROUND: Elucidation of the mechanisms by which gastric cancer cells acquire resistance to 5-fluorouracil (5FU) may provide important clues to the development of effective chemotherapy for 5FU-resistant gastric cancer METHODS: Four 5FU-resistant cell lines (MKN45/5FU, MKN74/5FU, NCI-N87/5FU, and...

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Detalhes bibliográficos
Main Authors: Nakamura, Ayako, Nakajima, Go, Okuyama, Ryuji, Kuramochi, Hidekazu, Kondoh, Yurin, Kanemura, Toshinori, Takechi, Teiji, Yamamoto, Masakazu, Hayashi, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Japan 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889291/
https://ncbi.nlm.nih.gov/pubmed/23494117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10120-013-0249-7
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