Design of an Optimized Wilms' Tumor 1 (WT1) mRNA Construct for Enhanced WT1 Expression and Improved Immunogenicity In Vitro and In Vivo

Tumor antigen–encoding mRNA for dendritic cell (DC)-based vaccination has gained increasing popularity in recent years. Within this context, two main strategies have entered the clinical trial stage: the use of mRNA for ex vivo antigen loading of DCs and the direct application of mRNA as a source of...

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Bibliographic Details
Main Authors: Benteyn, Daphné, Anguille, Sébastien, Van Lint, Sandra, Heirman, Carlo, Van Nuffel, An MT, Corthals, Jurgen, Ochsenreither, Sebastian, Waelput, Wim, Van Beneden, Katrien, Breckpot, Karine, Van Tendeloo, Viggo, Thielemans, Kris, Bonehill, Aude
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
Subjects:
Methods - Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889186/
https://ncbi.nlm.nih.gov/pubmed/24253259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.54
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