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Run-In Phase III Trial Design With Pharmacodynamics Predictive Biomarkers

BACKGROUND: Developments in biotechnology have stimulated the use of predictive biomarkers to identify patients who are likely to benefit from a targeted therapy. Several randomized phase III designs have been introduced for development of a targeted therapy using a diagnostic test. Most such design...

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Bibliografske podrobnosti
Main Authors: Hong, Fangxin, Simon, Richard
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888165/
https://ncbi.nlm.nih.gov/pubmed/24096624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djt265
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