Malate dehydrogenase 2 confers docetaxel resistance via regulations of JNK signaling and oxidative metabolism

BACKGROUND: Resistance to chemotherapy represents a significant obstacle in prostate cancer therapeutics. Novel mechanistic understandings in cancer cell chemotherapeutic sensitivity and resistance can optimize treatment and improve patient outcome. Molecular alterations in the metabolic pathways ar...

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Main Authors: Liu, Qiong, Harvey, Chris T., Geng, Hao, Xue, Changhui, Chen, Vivian, Beer, Tomasz M., Qian, David Z.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888097/
https://ncbi.nlm.nih.gov/pubmed/23389923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.22650
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