Structural Characterization of Native Autoinducing Peptides and Abiotic Analogs Reveals Key Features Essential for Activation and Inhibition of an AgrC Quorum Sensing Receptor in Staphylococcus aureus

Staphylococcus aureus is a major human pathogen that uses quorum sensing (QS) to control virulence. Its QS system is regulated by macrocyclic peptide signals (or autoinducing peptides (AIPs)) and their cognate transmembrane receptors (AgrCs). Four different specificity groups of S. aureus have been...

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Библиографические подробности
Главные авторы: Tal-Gan, Yftah, Ivancic, Monika, Cornilescu, Gabriel, Cornilescu, Claudia C., Blackwell, Helen E.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887510/
https://ncbi.nlm.nih.gov/pubmed/24219181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja407533e
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