Progesterone attenuates hemorrhagic transformation after delayed tPA treatment in an experimental model of stroke in rats: involvement of the VEGF–MMP pathway

Tissue plasminogen activator (tPA) is the only FDA-approved treatment for acute stroke, but its use remains limited. Progesterone (PROG) has shown neuroprotection in ischemia, but before clinical testing, we must determine how it affects hemorrhagic transformation in tPA-treated ischemic rats. Male...

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Autors principals: Won, Soonmi, Lee, Jin Hwan, Wali, Bushra, Stein, Donald G, Sayeed, Iqbal
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887344/
https://ncbi.nlm.nih.gov/pubmed/24045404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2013.163
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