An anti-leishmanial thiadiazine agent induces multiple myeloma cell apoptosis by suppressing the nuclear factor kappaB signalling pathway

BACKGROUND: Nuclear factor κB (NFκB) has a critical role in the pathophysiology of multiple myeloma. Targeting NFκB is an important strategy for anti-myeloma drug discovery. METHODS: Luciferase assay was used to evaluate the effects of DETT on NFκB activity. Annexin V–PI double staining and immunobl...

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Autori principali: Chen, G, Han, K, Xu, X, Du, X, Zhang, Z, Tang, J, Shi, M, Wang, M, Li, J, Cao, B, Mao, X
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887303/
https://ncbi.nlm.nih.gov/pubmed/24231956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.711
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