Gemcitabine enhances the efficacy of reovirus-based oncotherapy through anti-tumour immunological mechanisms

BACKGROUND: Reovirus preferentially infects and kills cancer cells and is currently undergoing clinical trials internationally. While oncolysis is the primary mode of tumour elimination, increasing evidence illustrates that reovirus additionally stimulates anti-tumour immunity with a capacity to tar...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gujar, S A, Clements, D, Dielschneider, R, Helson, E, Marcato, P, Lee, P W K
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
Schlagworte:
Translational Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887295/
https://ncbi.nlm.nih.gov/pubmed/24281006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.695
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