Automethylation Activities within the Mixed Lineage Leukemia-1 (MLL1) Core Complex Reveal Evidence Supporting a “Two-active Site” Model for Multiple Histone H3 Lysine 4 Methylation

The mixed lineage leukemia-1 (MLL1) core complex predominantly catalyzes mono- and dimethylation of histone H3 at lysine 4 (H3K4) and is frequently altered in aggressive acute leukemias. The molecular mechanisms that account for conversion of mono- to dimethyl H3K4 (H3K4me1,2) are not well understoo...

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Main Authors: Patel, Anamika, Vought, Valarie E., Swatkoski, Stephen, Viggiano, Susan, Howard, Benny, Dharmarajan, Venkatasubramanian, Monteith, Kelsey E., Kupakuwana, Gillian, Namitz, Kevin E., Shinsky, Stephen A., Cotter, Robert J., Cosgrove, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
DNA and Chromosomes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887211/
https://ncbi.nlm.nih.gov/pubmed/24235145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.501064
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