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Hyperactivation of Mammalian Target of Rapamycin Complex 1 (mTORC1) Promotes Breast Cancer Progression through Enhancing Glucose Starvation-induced Autophagy and Akt Signaling

The mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth and proliferation. Recent studies have suggested that constitutive activation of mTORC1 in normal cells could lead to malignant tumor development in several tissues. However, the mechanisms of mTORC1 hyperactiv...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Chen, Yongqiang, Wei, Huijun, Liu, Fei, Guan, Jun-Lin
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887183/
https://ncbi.nlm.nih.gov/pubmed/24275666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.526335
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