Effective Chemoimmunotherapy with Anti-TGFβ Antibody and Cyclophosphamide in a Mouse Model of Breast Cancer

TGFβ is reportedly responsible for accumulation of CD4(+)Foxp3(+) regulatory T cells (Tregs) in tumor. Thus, we treated mouse 4T1 mammary carcinoma with 1D11, a neutralizing anti-TGFβ (1,2,3) antibody. The treatment delayed tumor growth, but unexpectedly increased the proportion of Tregs in tumor. I...

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Autores principales: Chen, Xin, Yang, Yuan, Zhou, Qiong, Weiss, Jonathan M., Howard, OlaMae Zack, McPherson, John M., Wakefield, Lalage M., Oppenheim, Joost J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887137/
https://ncbi.nlm.nih.gov/pubmed/24416401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085398
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