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Bridging the Species Divide: Transgenic Mice Humanized for Type-I Interferon Response
We have generated transgenic mice that harbor humanized type I interferon receptors (IFNARs) enabling the study of type I human interferons (Hu-IFN-Is) in mice. These “HyBNAR” (Hybrid IFNAR) mice encode transgenic variants of IFNAR1 and IFNAR2 with the human extracellular domains being fused to tran...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
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Public Library of Science
2014
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Assuntos: | |
Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3887009/ https://ncbi.nlm.nih.gov/pubmed/24416207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084259 |
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