Assessment of the effect of TLR7/8, TLR9 agonists and CD40 ligand on the transformation efficiency of Epstein-Barr virus in human B lymphocytes by limiting dilution assay

Infection of human B cells with Epstein-Barr virus (EBV) induces polyclonal activation in almost all infected cells, but a small proportion of infected cells are transformed to immortalized lymphoblastoid cell lines. Since B cells are activated also by CD40 ligand (CD40L) and Toll-like receptor (TLR...

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Main Authors: Younesi, Vahid, Shirazi, Forough Golsaz, Memarian, Ali, Amanzadeh, Amir, Jeddi-Tehrani, Mahmood, Shokri, Fazel
Format: Artigo
Sprog:Inglês
Udgivet: Springer Netherlands 2013
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3886530/
https://ncbi.nlm.nih.gov/pubmed/23404520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-013-9542-x
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