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GILT: Shaping the MHC Class II-Restricted Peptidome and CD4(+) T Cell-Mediated Immunity
The MHC class II-restricted antigen processing pathway generates peptide:MHC complexes in the endocytic pathway for the activation of CD4(+) T cells. Gamma-interferon-inducible lysosomal thiol reductase (GILT) reduces protein disulfide bonds in the endocytic compartment, thereby exposing buried epit...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3885806/ https://ncbi.nlm.nih.gov/pubmed/24409178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00429 |
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