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Randomised Controlled Trials May Underestimate Drug Effects: Balanced Placebo Trial Design
BACKGROUND: It is an inherent assumption in randomised controlled trials that the drug effect can be estimated by subtracting the response during placebo from the response during active drug treatment. OBJECTIVE: To test the assumption of additivity. The primary hypothesis was that the total treatme...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3885519/ https://ncbi.nlm.nih.gov/pubmed/24416197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084104 |
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