Drug*placebo interaction effect may bias clinical trials interpretation: hybrid balanced placebo and randomized placebo-controlled design

BACKGROUND: Conventional randomized placebo-controlled study design assumes the absence of drug*placebo interaction. We hypothesized the presence of such an interaction and that conventionally estimated drug effect might be biased. The objectives of the study were to determine the drug*placebo inter...

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Detaylı Bibliyografya
Yayımlandı:BMC Med Res Methodol
Asıl Yazarlar: Hammami, Muhammad M., Hammami, Safa, Al-Swayeh, Reem, Al-Gaai, Eman, Farah, Faduma Abdi, De Padua, Sophia J. S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129641/
https://ncbi.nlm.nih.gov/pubmed/27899067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-016-0269-1
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