Pharmacokinetics, Brain Delivery, and Efficacy in Brain Tumor-Bearing Mice of Glutathione Pegylated Liposomal Doxorubicin (2B3-101)

Brain cancer is a devastating disease affecting many people worldwide. Effective treatment with chemotherapeutics is limited due to the presence of the blood-brain barrier (BBB) that tightly regulates the diffusion of endogenous molecules but also xenobiotics. Glutathione pegylated liposomal doxorub...

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Detalhes bibliográficos
Main Authors: Gaillard, Pieter J., Appeldoorn, Chantal C. M., Dorland, Rick, van Kregten, Joan, Manca, Francesca, Vugts, Danielle J., Windhorst, Bert, van Dongen, Guus A. M. S., de Vries, Helga E., Maussang, David, van Tellingen, Olaf
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885379/
https://ncbi.nlm.nih.gov/pubmed/24416140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082331
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