Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice

OBJECTIVE: Humanin (HN) is a cytoprotective peptide derived from endogenous mitochondria, expressed in the endothelial layer of human vessels, but its role in atherogenesis in vivo is not known. In vitro study, however, HN reduced oxidized low-density lipoprotein induced formation of reactive oxygen...

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Hauptverfasser: Oh, Yun K., Bachar, Adi R., Zacharias, David G., Kim, Sung Gyun, Wan, Junxiang, Cobb, Laura J., Lerman, Lilach O., Cohen, Pinchas, Lerman, Amir
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885346/
https://ncbi.nlm.nih.gov/pubmed/21763658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2011.06.038
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