Mechanistic Studies on the Reaction of Nitrocobalamin with Glutathione: Kinetic evidence for formation of an aquacobalamin intermediate

The essential but also toxic gaseous signaling molecule nitric oxide is scavenged by the reduced vitamin B(12) complex cob(II)alamin. The resulting complex, nitroxylcobalamin (NO(−)-Cbl(III)), is rapidly oxidized to nitrocobalamin (NO(2)Cbl) in the presence of oxygen; however it is unlikely that nit...

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Autores principales: Walker, David T., Dassanayake, Rohan S., Garcia, Kamille A., Mukherjee, Riya, Brasch, Nicola E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885173/
https://ncbi.nlm.nih.gov/pubmed/24415907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejic.201300254
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