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G17-modified hammerhead ribozymes are active in vitro and in vivo
Natural hammerhead ribozymes (HHRz) feature tertiary interactions between hairpin loops or bulges in two of three helices that surround the catalytic core of conserved nucleotides. Their conservation was originally established on minimal versions lacking the tertiary interactions. While those sequen...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3884650/ https://ncbi.nlm.nih.gov/pubmed/24145822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.040543.113 |
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