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Synthetic Lethality Screen Identifies RPS6KA2 as Modifier of Epidermal Growth Factor Receptor Activity in Pancreatic Cancer
Pancreatic cancer is characterized by a high degree of resistance to chemotherapy. Epidermal growth factor receptor (EGFR) inhibition using the small-molecule inhibitor erlotinib was shown to provide a small survival benefit in a subgroup of patients. To identify kinases whose inhibition acts synerg...
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Auteurs principaux: | , , , , , , , , , , , |
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Format: | Artigo |
Langue: | Inglês |
Publié: |
Neoplasia Press Inc.
2013
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Sujets: | |
Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3884526/ https://ncbi.nlm.nih.gov/pubmed/24403857 |
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