Synthetic Lethality Screen Identifies RPS6KA2 as Modifier of Epidermal Growth Factor Receptor Activity in Pancreatic Cancer

Pancreatic cancer is characterized by a high degree of resistance to chemotherapy. Epidermal growth factor receptor (EGFR) inhibition using the small-molecule inhibitor erlotinib was shown to provide a small survival benefit in a subgroup of patients. To identify kinases whose inhibition acts synerg...

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Detalhes bibliográficos
Main Authors: Milosevic, Nada, Kühnemuth, Benjamin, Mühlberg, Leonie, Ripka, Stefanie, Griesmann, Heidi, Lölkes, Carolin, Buchholz, Malte, Aust, Daniela, Pilarsky, Christian, Krug, Sebastian, Gress, Thomas, Michl, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3884526/
https://ncbi.nlm.nih.gov/pubmed/24403857
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