Supplementation of Nicotinic Acid with NAMPT Inhibitors Results in Loss of In Vivo Efficacy in NAPRT1-Deficient Tumor Models

Nicotinamide adenine dinucleotide (NAD) is a metabolite essential for cell survival and generated de novo from tryptophan or recycled from nicotinamide (NAM) through the nicotinamide phosphoribosyltransferase (NAMPT)-dependent salvage pathway. Alternatively, nicotinic acid (NA) is metabolized to NAD...

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Main Authors: O'Brien, Thomas, Oeh, Jason, Xiao, Yang, Liang, Xiaorong, Vanderbilt, Alexander, Qin, Ann, Yang, Lulu, Lee, Leslie B, Ly, Justin, Cosino, Ely, LaCap, Jennifer A, Ogasawara, Annie, Williams, Simon, Nannini, Michelle, Liederer, Bianca M, Jackson, Peter, Dragovich, Peter S, Sampath, Deepak
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press Inc. 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3884523/
https://ncbi.nlm.nih.gov/pubmed/24403854
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