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Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis

OBJECTIVE: Hypomethylation of LINE-1 elements has emerged as a distinguishing feature in human cancers. Limited evidence indicates that some LINE-1 elements encode an additional internal antisense promoter, and increased hypomethylation of this region may lead to inadvertent activation of evolutiona...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hur, Keun, Cejas, Paloma, Feliu, Jaime, Moreno-Rubio, Juan, Burgos, Emilio, Boland, C Richard, Goel, Ajay
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3884067/
https://ncbi.nlm.nih.gov/pubmed/23704319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2012-304219
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