Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer

In colorectal cancer (CRC) the vitamin D catabolizing enzyme 1,25-dihydroxyvitamin D 24-hydroxylase (CYP24A1) is overexpressed with a potentially significant, positive impact on the catabolism of 1,25-dihydroxyvitamin D(3) (1,25-D(3)). However, the underlying mechanism of CYP24A1 overexpression is p...

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Dettagli Bibliografici
Autori principali: Höbaus, Julia, Hummel, Doris M, Thiem, Ursula, Fetahu, Irfete S, Aggarwal, Abhishek, Müllauer, Leonhard, Heller, Gerwin, Egger, Gerda, Mesteri, Ildiko, Baumgartner-Parzer, Sabina, Kallay, Enikö
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2013
Soggetti:
Cancer Genetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807607/
https://ncbi.nlm.nih.gov/pubmed/23463632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.28143
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