mRNA Levels of Related Abcb Genes Change Opposite to Each Other upon Histone Deacetylase Inhibition in Drug-Resistant Rat Hepatoma Cells

The multidrug-resistant phenotype of tumor cells is acquired via an increased capability of drug efflux by ABC transporters and causes serious problems in cancer treatment. With the aim to uncover whether changes induced by epigenetic mechanisms in the expression level of drug transporter genes corr...

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Bibliographic Details
Main Authors: Sike, Ádám, Nagy, Enikő, Vedelek, Balázs, Pusztai, Dávid, Szerémy, Péter, Venetianer, Anikó, Boros, Imre M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883685/
https://ncbi.nlm.nih.gov/pubmed/24409311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084915
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