Decreased Mutation Frequencies among Immunoglobulin G Variable Region Genes during Viremic HIV-1 Infection

BACKGROUND/OBJECTIVE: HIV-1 infection is complicated by high rates of opportunistic infections against which specific antibodies contribute to immune defense. Antibody function depends on somatic hypermutation (SHM) of variable regions of immunoglobulin heavy chain genes (V(H)-D-J). We characterized...

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Autors principals: Bowers, Elisabeth, Scamurra, Ronald W., Asrani, Anil, Beniguel, Lydie, MaWhinney, Samantha, Keays, Kathryne M., Thurn, Joseph R., Janoff, Edward N.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883639/
https://ncbi.nlm.nih.gov/pubmed/24409278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081913
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