Decreased Mutation Frequencies among Immunoglobulin G Variable Region Genes during Viremic HIV-1 Infection

BACKGROUND/OBJECTIVE: HIV-1 infection is complicated by high rates of opportunistic infections against which specific antibodies contribute to immune defense. Antibody function depends on somatic hypermutation (SHM) of variable regions of immunoglobulin heavy chain genes (V(H)-D-J). We characterized...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Bowers, Elisabeth, Scamurra, Ronald W., Asrani, Anil, Beniguel, Lydie, MaWhinney, Samantha, Keays, Kathryne M., Thurn, Joseph R., Janoff, Edward N.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2014
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883639/
https://ncbi.nlm.nih.gov/pubmed/24409278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081913
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