Decreased Mutation Frequencies among Immunoglobulin G Variable Region Genes during Viremic HIV-1 Infection

BACKGROUND/OBJECTIVE: HIV-1 infection is complicated by high rates of opportunistic infections against which specific antibodies contribute to immune defense. Antibody function depends on somatic hypermutation (SHM) of variable regions of immunoglobulin heavy chain genes (V(H)-D-J). We characterized...

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Main Authors: Bowers, Elisabeth, Scamurra, Ronald W., Asrani, Anil, Beniguel, Lydie, MaWhinney, Samantha, Keays, Kathryne M., Thurn, Joseph R., Janoff, Edward N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883639/
https://ncbi.nlm.nih.gov/pubmed/24409278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081913
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