IDH1 and IDH2 mutations in pediatric acute leukemia

To investigate the frequency of isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) mutations in pediatric acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), we sequenced these genes in diagnostic samples from 515 patients (227 AMLs and 288 ALLs). Somatic IDH1/IDH2 mutations were rare in ALL...

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Huvudupphovsmän: Andersson, Anna K, Miller, David W, Lynch, John A, Lemoff, Andrew S, Cai, Zhongling, Pounds, Stanley B, Radtke, Ina, Yan, Bing, Schuetz, John D, Rubnitz, Jeffrey E, Ribeiro, Raul C, Raimondi, Susana C, Zhang, Jinghui, Mullighan, Charles G, Shurtleff, Sheila A, Schulman, Brenda A, Downing, James R
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883450/
https://ncbi.nlm.nih.gov/pubmed/21647154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.133
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