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Common and New Acyclovir Resistant Herpes Simplex Virus-1 Mutants Causing Bilateral Recurrent Herpetic Keratitis in an Immunocompetent Patient

We investigated thymidine kinase (tk) mutants isolated during multiple episodes of recurrent bilateral acyclovir resistant herpes simplex keratitis in an immunocompetent patient. From one eye, we found a single guanine insertion, previously shown to greatly reduce TK expression, and from the other,...

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Autori principali: Pan, Dongli, Kaye, Stephen B., Hopkins, Mark, Kirwan, Ruaidhri, Hart, Ian J., Coen, Donald M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883165/
https://ncbi.nlm.nih.gov/pubmed/23945375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit437
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