PECAM-1 and caveolae form the mechanosensing complex necessary for NOX2 activation and angiogenic signaling with stopped flow in pulmonary endothelium

We showed that stop of flow triggers a mechanosignaling cascade that leads to the generation of reactive oxygen species (ROS); however, a mechanosensor coupled to the cytoskeleton that could potentially transduce flow stimulus has not been identified. We showed a role for K(ATP) channel, caveolae (c...

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Detalhes bibliográficos
Main Authors: Noel, John, Wang, Hui, Hong, Nankang, Tao, Jian-Qin, Yu, Kevin, Sorokina, Elena M., DeBolt, Kristine, Heayn, Michelle, Rizzo, Victor, Delisser, Horace, Fisher, Aron B., Chatterjee, Shampa
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882530/
https://ncbi.nlm.nih.gov/pubmed/24077950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00123.2013
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