Metformin-stimulated AMPK-α1 promotes microvascular repair in acute lung injury

Acute lung injury secondary to sepsis is a leading cause of mortality in sepsis-related death. Present therapies are not effective in reversing endothelial cell dysfunction, which plays a key role in increased vascular permeability and compromised lung function. AMP-activated protein kinase (AMPK) i...

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Main Authors: Jian, Ming-Yuan, Alexeyev, Mikhail F., Wolkowicz, Paul E., Zmijewski, Jaroslaw W., Creighton, Judy R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882528/
https://ncbi.nlm.nih.gov/pubmed/24097562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00173.2013
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