A test of the hypothesis that oxalate secretion produces proximal tubule crystallization in primary hyperoxaluria type I

The sequence of events by which primary hyperoxaluria type 1 (PH1) causes renal failure is unclear. We hypothesize that proximal tubule (PT) is vulnerable because oxalate secretion raises calcium oxalate (CaOx) supersaturation (SS) there, leading to crystal formation and cellular injury. We studied...

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Detalhes bibliográficos
Main Authors: Worcester, Elaine M., Evan, Andrew P., Coe, Fredric L., Lingeman, James E., Krambeck, Amy, Sommers, Andre, Phillips, Carrie L., Milliner, Dawn
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882369/
https://ncbi.nlm.nih.gov/pubmed/24089413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00382.2013
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