A test of the hypothesis that oxalate secretion produces proximal tubule crystallization in primary hyperoxaluria type I

The sequence of events by which primary hyperoxaluria type 1 (PH1) causes renal failure is unclear. We hypothesize that proximal tubule (PT) is vulnerable because oxalate secretion raises calcium oxalate (CaOx) supersaturation (SS) there, leading to crystal formation and cellular injury. We studied...

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Bibliografski detalji
Glavni autori: Worcester, Elaine M., Evan, Andrew P., Coe, Fredric L., Lingeman, James E., Krambeck, Amy, Sommers, Andre, Phillips, Carrie L., Milliner, Dawn
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2013
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Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882369/
https://ncbi.nlm.nih.gov/pubmed/24089413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00382.2013
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