Exploiting the Synergy between Carboplatin and ABT-737 in the Treatment of Ovarian Carcinomas

Platinum drug-resistance in ovarian cancers mediated by anti-apoptotic proteins such as Bcl-xL is a major factor contributing to the chemotherapeutic resistance of recurrent disease. Consequently, concurrent inhibition of Bcl-xL in combination with chemotherapy may improve treatment outcomes for pat...

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Bibliographic Details
Main Authors: Jain, Harsh Vardhan, Richardson, Alan, Meyer-Hermann, Michael, Byrne, Helen M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882219/
https://ncbi.nlm.nih.gov/pubmed/24400068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081582
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