Global IRS-1 phosphorylation analysis in insulin resistance

AIMS/HYPOTHESIS: IRS-1 serine phosphorylation is often elevated in insulin resistance models, but confirmation in vivo in humans is lacking. We therefore analysed IRS-1 phosphorylation in human muscle in vivo. METHODS: We used HPLC-electrospray ionisation (ESI)-MS/MS to quantify IRS-1 phosphorylatio...

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Main Authors: Langlais, P., Yi, Z., Finlayson, J., Luo, M., Mapes, R., De Filippis, E., Meyer, C., Plummer, E., Tongchinsub, P., Mattern, M., Mandarino, L. J.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882165/
https://ncbi.nlm.nih.gov/pubmed/21850561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-011-2271-9
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