Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts

To characterize patient-derived xenografts (PDXs) for functional studies, we made whole-genome comparisons with originating breast cancers representative of the major intrinsic subtypes. Structural and copy number aberrations were found to be retained with high fidelity. However, at the single-nucle...

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Detalhes bibliográficos
Main Authors: Li, Shunqiang, Shen, Dong, Shao, Jieya, Crowder, Robert, Liu, Wenbin, Prat, Aleix, He, Xiaping, Liu, Shuying, Hoog, Jeremy, Lu, Charles, Ding, Li, Griffith, Obi L., Miller, Christopher, Larson, Dave, Fulton, Robert S., Harrison, Michelle, Mooney, Tom, McMichael, Joshua F., Luo, Jingqin, Tao, Yu, Goncalves, Rodrigo, Schlosberg, Christopher, Hiken, Jeffrey F., Saied, Laila, Sanchez, Cesar, Giuntoli, Therese, Bumb, Caroline, Cooper, Crystal, Kitchens, Robert T., Lin, Austin, Phommaly, Chanpheng, Davies, Sherri R., Zhang, Jin, Kavuri, Megha Shyam, McEachern, Donna, Dong, Yi Yu, Ma, Cynthia, Pluard, Timothy, Naughton, Michael, Bose, Ron, Suresh, Rama, McDowell, Reida, Michel, Loren, Aft, Rebecca, Gillanders, William, DeSchryver, Katherine, Wilson, Richard K., Wang, Shaomeng, Mills, Gordon B., Gonzalez-Angulo, Ana, Edwards, John R., Maher, Christopher, Perou, Charles M., Mardis, Elaine R., Ellis, Matthew J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3881975/
https://ncbi.nlm.nih.gov/pubmed/24055055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.08.022
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