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Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology

Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progressio...

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Bibliografische gegevens
Hoofdauteurs: Husain, Zaheed, Seth, Pankaj, Sukhatme, Vikas P
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Landes Bioscience 2013
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3881600/
https://ncbi.nlm.nih.gov/pubmed/24404426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.26383
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