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Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology
Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progressio...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Landes Bioscience
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3881600/ https://ncbi.nlm.nih.gov/pubmed/24404426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.26383 |
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