SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis

The epithelial-to-mesenchymal transition (EMT) is important for the development of cancer metastases and organ fibrosis, conditions prevalent in aging. Because sirtuins affect the pathology of aging, we tested the effect of SirT1 on EMT. Reduced SIRT1 levels in HMLER breast cancer cells led to incre...

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Main Authors: Simic, Petra, Williams, Eric O., Bell, Eric L., Gong, Jing Jing, Bonkowski, Michael, Guarente, Leonard
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3881428/
https://ncbi.nlm.nih.gov/pubmed/23583181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.03.019
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