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TIMP-2 mutant decreases MMP-2 activity and augments pressure overload induced LV dysfunction and heart failure

Pressure overload induces cardiac extracellular matrix (ECM) remodelling and results in heart failure. ECM remodelling by matrix metalloproteinases (MMPs) is primarily regulated by their target inhibitors, tissue inhibitor of matrix metalloproteinases (TIMPs). It is known that TIMP-2 is highly expre...

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Bibliografische gegevens
Hoofdauteurs: Givvimani, S., Kundu, S., Narayanan, N., Armaghan, F., Qipshidze, N., Pushpakumar, S., Vacek, T. P., Tyagi, S. C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3881363/
https://ncbi.nlm.nih.gov/pubmed/23398532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/13813455.2012.755548
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