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TIMP-2 mutant decreases MMP-2 activity and augments pressure overload induced LV dysfunction and heart failure
Pressure overload induces cardiac extracellular matrix (ECM) remodelling and results in heart failure. ECM remodelling by matrix metalloproteinases (MMPs) is primarily regulated by their target inhibitors, tissue inhibitor of matrix metalloproteinases (TIMPs). It is known that TIMP-2 is highly expre...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3881363/ https://ncbi.nlm.nih.gov/pubmed/23398532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/13813455.2012.755548 |
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