Escalating regulation of 5T4-specific IFN-γ(+) CD4(+) T cells distinguishes colorectal cancer patients from healthy controls and provides a target for in vivo therapy

The relationship between the adaptive CD4(+) T cell response and human cancer is unclear. The oncofetal antigen 5T4 is expressed on many human carcinomas, including colorectal cancer (CRC) cells, but has limited expression on normal tissues. We previously identified anti-5T4 CD4(+) T cells in a prop...

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Bibliografiske detaljer
Main Authors: Scurr, Martin, Bloom, Anja, Pembroke, Tom, Srinivasan, Rohit, Brown, Clare, Smart, Kathryn, Bridgeman, Hayley, Davies, Mike, Hargest, Rachel, Phillips, Simon, Christian, Adam, Hockey, Tom, Gallimore, Awen, Godkin, Andrew
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880929/
https://ncbi.nlm.nih.gov/pubmed/24409450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0035
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